細菌建立自己的防御性的效果
<p class="MsoNormal"><strong><span style="background-color: rgb(255, 255, 153);"><span style="font-family: 宋體; font-size: 9pt;"><font face="宋體">研究人員發(fā)現(xiàn)了關(guān)于</font>“細菌如何生長和繁殖”的重要新信息,可能有助于發(fā)現(xiàn)極為需要的新抗生素藥物。</span></span></strong><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;">所有細胞都有一個外層,在重要的遺傳信息周圍形成一個保護屏障。</span><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;">對于一些細菌來說,當它們在體內(nèi)傳播時,一個牢固的外層有助于入侵細胞幸免于攻擊;這種保護層是許多常用抗生素的靶標。然而,當細菌細胞分裂并在體內(nèi)傳播時,這些保護層是如何發(fā)展的,關(guān)于這方面的知識還存在很多漏洞。</span><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"> </span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><font face="宋體">細菌通過細胞分裂進行傳播;一旦細菌細胞長到其完整尺寸,它就開始收緊圍繞其中部的一條帶子,條帶變得比以往任何時候都緊,直到它</font>zui<font face="宋體">終將舊的細胞分裂成兩個單獨的細胞。</font></span><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;">當這一過程發(fā)生時,細胞必須精確復(fù)制它的基因組,以便每一個新的細菌細胞都包含跟其他細胞相同的遺傳信息。以這種方式,細菌確保它們在體內(nèi)傳播時,在每個新的細胞中保持強大的防御機制。</span><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"> </span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><font face="宋體">但是現(xiàn)在,來自紐卡斯爾大學(xué)的一個研究小組利用</font>Diamond <font face="宋體">的</font><font face="Calibri">I04-1</font><font face="宋體">光束的強大</font><font face="Calibri">X</font><font face="宋體">射線光,來確定幫助驅(qū)動這個分而治之系統(tǒng)的蛋白質(zhì)的原子結(jié)構(gòu)。</font><font face="Calibri">EzrA</font><font face="宋體">是調(diào)節(jié)細胞分裂過程的一種重要蛋白質(zhì)。</font></span><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><font face="宋體">它有助于控制另外一個蛋白質(zhì)</font>FtsZ<font face="宋體">,該蛋白管理引起細菌細胞分裂為二的條帶的緊縮。然而,</font><font face="Calibri">FtsZ</font><font face="宋體">的原子構(gòu)造已經(jīng)弄清,現(xiàn)在,先進的同步加速器技術(shù),可讓科學(xué)家們進一步揭示支持這一過程的蛋白質(zhì)</font><font face="Calibri">EzrA</font><font face="宋體">。</font></span><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"> </span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;">EzrA<font face="宋體">結(jié)構(gòu)的發(fā)現(xiàn)特別有意義,因為它可以幫助確定未來抗生素的新靶點。理解</font><font face="Calibri">EzrA</font><font face="宋體">的原子結(jié)構(gòu),可以幫助科學(xué)家開發(fā)出禁用它的方法,從而防止細菌正確地分裂。</font></span><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;">沒有這些至關(guān)重要的蛋白質(zhì),細菌在其分裂和傳播時,就無法為每一個新細胞產(chǎn)生一個保護性細胞壁,從而使新的細胞暴露于攻擊之下。</span><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"> </span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><font face="宋體">研究表明</font>EzrA<font face="宋體">蛋白的原子結(jié)構(gòu)既美麗又復(fù)雜。</font><font face="Calibri">EzrA</font><font face="宋體">的形狀是一種不尋常的構(gòu)象,就像一個圈,它的中間能夠容納條帶緊縮蛋白</font><font face="Calibri">FtsZ</font><font face="宋體">。</font><font face="Calibri">EzrA</font><font face="宋體">的圈形構(gòu)造,可以防止</font><font face="Calibri">FtsZ</font><font face="宋體">蛋白逃逸,直到它已經(jīng)完成其目的:致使細胞條帶收縮和將細胞分裂為二,同時親本細胞的基因組被復(fù)制和傳遞給子代。</font></span><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"> </span></p>
<p class="MsoNormal"><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><font face="宋體">因為科學(xué)技術(shù)的進步,深入研究生物的原子結(jié)構(gòu),正變得越來越可行。強大的科學(xué)機器可讓科學(xué)家們看到太小、用標準顯微鏡無法看到的東西。自成立以來,我司一直都支持解析</font>2000<font face="宋體">多種這樣的蛋白質(zhì)結(jié)構(gòu)。</font></span><span style="mso-spacerun:'yes';font-family:宋體;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:9.0000pt;mso-font-kerning:1.0000pt;"><o:p></o:p></span></p>